Send Page to a friendAcai (Euterpe oleracea Mart.) polyphenolics in their glycoside and aglycone forms induce apoptosis of HL-60 leukemia cells.
J Agric Food Chem. 2006 Feb 22;54(4):1222-9.
Del Pozo-Insfran D, Percival SS, Talcott ST.
Department of Food Science and Human Nutrition, University of Florida, P.O. Box 110370, Gainesville, Florida 32611-0370.
The effects of acai polyphenolics on the antiproliferation and induction of apoptosis in HL-60 human leukemia cells were investigated. Interactions between anthocyanins and non-anthocyanin-polyphenolics in both their glycosidic and their aglycone forms were also investigated to determine additive or non-additive responses. Polyphenolic fractions at 0.17-10.7 muM were found to reduce cell proliferation from 56 to 86% likely due to caspase-3 activation (apoptosis). Anthocyanin and polyphenolic fractions were non-additive in their contribution to the cell antiproliferation activity. At equimolar concentrations, the glycosidic forms of phenolic acids and flavonoids induced a higher magnitude of change in cell parameters (proliferation and apoptosis) than their respective aglycone forms, while the opposite trend was observed for anthocyanin aglycones. This study demonstrated that acai offers a rich source of bioactive polyphenolics and confirmed the importance of investigating whole food systems when evaluating the potential health benefits of individual phytochemical compounds.
Recognized as a powerful antioxidant source, the tropical palmberry, acai, is used in Berry Wise products to boost ORAC. This in vitro study on human leukemia (blood cancer) cells demonstrates that phenolic antioxidants from acai inhibit the proliferation of these cancer cells.
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