Send Page to a friendBlack raspberry extract and fractions contain angiogenesis inhibitors.
J Agric Food Chem. 2005 May 18;53(10):3909-15.
Liu Z, Schwimer J, Liu D, Greenway FL, Anthony CT, Woltering EA.
Louisiana State University Agricultural Center, 227 Renewable Natural Resources Building, Baton Rouge, Louisiana 70803, USA.
Targeted therapies, such as agents that inhibit angiogenesis, offer hope as complementary agents in cancer therapy. Angiogenesis-inhibiting agents have the potential for inhibiting tumor growth and limiting the dissemination of metastasis, thus keeping cancers in a static growth state for prolonged periods. Black raspberry (Rubus occidentalis) extract was discovered to be antiangiogenic (0.1% w/v) in a novel human tissue-based in vitro fibrin clot angiogenesis assay. Assay-guided fractionation of a crude black raspberry extract resulted in a highly potent antiangiogenic fraction that accounted for only 1% of the fresh weight of whole black raspberries. At 0.075% (w/v), the active fraction completely inhibited angiogenic initiation and angiogenic vessel growth. Further subfractionation of this active fraction revealed the coexistence of multiple antiangiogenic compounds, one of which has been identified as gallic acid. However, the individual subfractions did not outperform the active whole fraction. These findings suggest that an active black raspberry fraction may be a promising complementary cancer therapy. It is natural and potent enough for manageable dosing regimens. These extracts contain multiple active ingredients that may be additive or synergistic in their antiangiogenic effects. These observations warrant further investigations in animals and human trials.
Black raspberries are unusually rich in antioxidants becoming a focus in cancer research. Among the many phenolics found in black raspberries, ellagic acid in this study and ferulic acid from other research are emerging as primary anti-cancer antioxidants.
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